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Total 6414 results found since Jan 2013.
Effect of Intracoronary Metformin on Myocardial Infarct Size in Swine.
CONCLUSIONS: In contrast to rodent hearts, postconditioning with high-dose metformin administered immediately before reperfusion does not reduce IS or improve LV function 7 days after myocardial infarction in swine. These results reinforce the importance of rigorously testing therapies in large animal models to facilitate clinical translation of novel cardioprotective therapies.
PMID: 30355033 [PubMed - in process]
Source: Circulation Research - September 28, 2018 Category: Cardiology Authors: Techiryan G, Weil BR, Palka BA, Canty JM Tags: Circ Res Source Type: research
Advanced onset of puberty after metformin therapy in swine with thrifty genotype
This article is protected by copyright. All rights reserved
Source: Experimental Physiology - July 1, 2014 Category: Physiology Authors: S. Astiz, A. Gonzalez‐Bulnes, I. Astiz, A. Barbero, Perez‐Solana, I. Garcia‐Real Tags: Themed Issue Source Type: research
Metabolic programming in the offspring after gestational overfeeding in the mother: toward neonatal rescuing with metformin in a swine model
International Journal of Obesity, Published online: 28 January 2022; doi:10.1038/s41366-022-01076-5Metabolic programming in the offspring after gestational overfeeding in the mother: toward neonatal rescuing with metformin in a swine model
Source: International Journal of Obesity - January 28, 2022 Category: Eating Disorders & Weight Management Authors: S ílvia Xargay-Torrent Berta Mas-Par és Gemma Carreras-Badosa Esther Liz árraga-Mollinedo Joan Tibau Josep Reixach Est íbaliz Platero-Gutierrez Anna Prats-Puig Francis De Zegher Lourdes Ib áñez Judit Bassols Abel L ópez-Bermejo Source Type: research
In search of the mechanisms of metformin in cancer
In search of the mechanisms of metformin in cancer, Published online: 26 September 2018; doi:10.1038/s41574-018-0104-3In search of the mechanisms of metformin in cancer
Source: Nature Reviews Endocrinology - September 26, 2018 Category: Endocrinology Authors: Alan Morris Source Type: research
Metformin does not affect risk of biochemical recurrence following radical prostatectomy: results from the SEARCH database
rman
& S J Freedland
Source: Prostate Cancer and Prostatic Diseases - October 8, 2013 Category: Urology & Nephrology Authors: E H AllottM R AbernL GerberC J KetoW J AronsonM K TerrisC J KaneC L AmlingM R CooperbergP G MoormanS J Freedland Tags: metformin diabetes biochemical recurrence outcomes Source Type: research
Using Age-Related Gene Expression Changes to Search for Drugs to Slow Aging
In this study, using gene expression data for human brain ageing, we aimed to discover not only new pro-longevity drugs but also those that can improve health during ageing. The biological processes showing a change in expression include pathways related to synaptic and cognitive functions as well as proteostasis, suggesting gene expression changes in the ageing brain could be used as a surrogate to find drugs to target detrimental effects.
Using multiple gene expression datasets from brain tissue, taken from patients of different ages, we first identified the expression changes that characterise ageing. Then, we c...
Source: Fight Aging! - July 2, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Search list of recalled metformin products
Source: FDA Center for Drug Evaluation and Research - What's New - July 13, 2020 Category: Drugs & Pharmacology Authors: FDA Source Type: news
Fight Aging! Newsletter, October 2nd 2017
This study featured two independent experiments. The first established the safety of administering a therapeutic gene delivery vector, BNP116, created from an inactivated virus over three months, into 48 pigs without heart failure through the coronary arteries via catheterization using echocardiography. The second experiment examined the efficacy of the treatment in 13 pigs with severe heart failure induced by mitral regurgitation. Six pigs received the gene and 7 received a saline solution.
The researchers determined that the gene therapy was safe and significantly reversed heart failure by 25 percent in the left v...
Source: Fight Aging! - October 1, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, January 22nd 2018
In conclusion, death is a natural part of human existence, but human progress is essentially a story of overcoming undesirable natural limits. In the near future, technological progress might make it possible to stop natural biological death. Should humankind embrace such technology? Yes: Even though such technology would not be without risks, the risks are almost certainly manageable. The benefits of ending natural death, on the other hand, are immense. Death is an obstacle that is slowing down human progress. If we remove that obstacle, humankind could increase the speed of both its moral and its epistemic progress.
...
Source: Fight Aging! - January 21, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, March 27th 2017
In conclusion, DNAm of multiple disease-related genes are strongly linked to mortality outcomes.
The recently established epigenetic clock (DNAm age) has received growing attention as an increasing number of studies have uncovered it to be a proxy of biological ageing and thus potentially providing a measure for assessing health and mortality. Intriguingly, we targeted mortality-related DNAm changes and did not find any overlap with previously established CpGs that are used to determine the DNAm age. Our findings are in line with evidence, suggesting that DNAm involved in ageing or health-related outcomes are mostly...
Source: Fight Aging! - March 26, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, January 27th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - January 26, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
AZ at it again
AUTH/2793/9/15 - Clinical pharmacist v AstraZenecaCase number:AUTH/2793/9/15Case ref:Clinical pharmacist v AstraZenecaDescription:Identifying patients suitable for Forxiga treatment and failing to provide an accurate response to the PanelNo breach:No breaches Clauses 2 and 7.2Breach:Breaches Clauses 3.2, 7.2 and 9.1. Corrective statement and public reprimand.Appeal:No appealReview:Published in the May 2016 ReviewReceived:10/09/2015Completed:17/03/20162793Case Summary:A clinical pharmacist complained about an AstraZeneca leavepiece about how to create a clinical system search to identify patients suitable for tr...
Source: PharmaGossip - September 27, 2016 Category: Pharmaceuticals Authors: insider Source Type: blogs
Law and Order? - Bristol-Myers-Squibb Settles Case Alleging Fraud and Kickbacks, No Admissions of Guilt, No Individuals Charged
Introduction Donald Trump, Republican candidate for the US presidency last week announced he is the " law and order " candidate, accompanied by then vice presidential contender and New Jersey Governor Chris Christie. I wonder if all this interest in law and order will lead to increasing the effectiveness of enforcing laws when large US health care corporations are accused? For years, we have been watching a parade of legal settlements made by big US health care organizations. These have included the biggest drug companies, biotechnology companies, device companies, insurance companies, etc, etc. ...
Source: Health Care Renewal - July 21, 2016 Category: Health Management Tags: Abilify Bristol-Myers-Squibb crime impunity kickbacks legal settlements logical fallacies Source Type: blogs
Fight Aging! Newsletter, July 9th 2018
In this study, senescent cell distribution and quantity in vastus lateralis muscle were examined in young human adults after a single bout of resistance exercise. To determine the effects of dietary protein availability around exercise on senescent cell quantity and macrophage infiltration of skeletal muscle, two isocaloric protein supplements (14% and 44% in calorie) were ingested before and immediately after an acute bout of resistance exercise, in a counter-balanced crossover fashion. An additional parallel trial was conducted to compare the outcome of muscle mass increment under the same dietary conditions after 12 wee...
Source: Fight Aging! - July 8, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
